Feb 16, 2023 · nausea, vomiting, diarrhea, bloating, stomach pain; itching, rash, or other skin problems; cold or flu symptoms such as stuffy nose, sneezing, sore throat, cough; headache, migraine; or. pain anywhere in your body. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Label: BRILLIA HEALTH COUGH CONTROL (lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin- 12c, 30c, 50c tabletBRILLIA ADULT (lapine s-100 immune globulin 12 hpc, 30 hpc, 200 hpc) pill NDC Code(s): 72123-003-01 BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill Out of scope - Out of scope for RxNorm and will not receive RxNorm normal forms. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. Brillia’s active ingredient is Lapine S-100B immune globulin, which is produced using antibodies. S-100B is a protein in the brain that is essential for regulating many processes,...Label: BRILLIA HEALTH COLD-FLU RECOVERY (lapine histamine immune globulin (12c, 30c, 50c), lapine interferon gamma immune globulin (12c, 30c, 50c), lapine cd4 immune globulin- 12c, 30c, 50c tabletBrillia (Children's) Active ingredients Lapine S-100 immune globulin 12C, 30C, and 50C Inactive Ingredients Lactose monohydrate, Magnesium stearate, Microcrystaline cellulose Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Uses reduce feelings of anxiety, excitability, and stress BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill Out of scope - Out of scope for RxNorm and will not receive RxNorm normal forms. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food.SEARCH RESULTS for: IMMUNE GLOBULIN (63 results) Sharemuscle cramps. muscle pain. nausea. pain, redness, or irritation at site where injected. tiredness. This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.ACTIVE INGREDIENT. Active ingredients. Lapine S-100 immune globulin 12C, 30C, and 50C. INACTIVE INGREDIENT. Inactive Ingredients. Lactose monohydrate, Magnesium stearate, Microcrystaline cellulose. KEEP OUT OF REACH OF CHILDREN. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.Label: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos. Drug Label Info. Safety ...Label: BRILLIA HEALTH COLD-FLU RECOVERY (lapine histamine immune globulin (12c, 30c, 50c), lapine interferon gamma immune globulin (12c, 30c, 50c), lapine cd4 immune globulin- 12c, 30c, 50c tabletBRILLIA HEALTH COUGH CONTROL- lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin (12c, 30c, 50c) tablet Hadaf LLC. Disclaimer: This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy.BRILLIA HEALTH COUGH CONTROL (lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin- 12c, 30c, 50c tablet If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be specified as such. Label: BRILLIA HEALTH COUGH CONTROL (lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin- 12c, 30c, 50c tabletLabel: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos ...a new way to combine homeopathy and antibody science. The active ingredient of Brillia, Lapine S-100 immune globulin, is produced using antibodies to the brain-specific S-100 protein (S-100B). This protein is an essential regulator of many different intracellular and extracellular brain processes, e.g., various enzyme activities, Label: BRILLIA HEALTH COUGH CONTROL (lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin- 12c, 30c, 50c tablet The source material of Immune Globulin (Human) shall be plasma recovered from Whole Blood prepared as prescribed in §§ 640.1 through 640.5, or Source Plasma prepared as prescribed in §§ 640.60 through 640.76. (c) Additives in source material. BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill Out of scope - Out of scope for RxNorm and will not receive RxNorm normal forms. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food.Jan 18, 2022 · Label: BRILLIA ADULT- lapine s-100 immune globulin 12 hpc, 30 hpc, 200 hpc pill. DISCLAIMER: This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy. FDA is not aware of scientific evidence to support homeopathy as effective. Label: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos ...Difficulty having a bowel movement (stool) headache. increased urination. nausea. stomach cramps.Generic name: immune globulin intravenous. 7.0. 2 reviews. Asceniv ( Pro) Generic name: immune globulin intravenous. 10. 2 reviews. Rhophylac ( Pro) Generic name: rho (d) immune globulin. Label: BRILLIA HEALTH COUGH CONTROL (lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin- 12c, 30c, 50c tablet immune globulin (intravenous) can cause blood clots. The risk is highest in older adults or in people who have had blood clots, heart problems, or blood circulation problems. Blood clots are also more likely during long-term bedrest, while using birth control pills or hormone replacement therapy, or while having a central intravenous (IV ...BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill Hadaf LLC Disclaimer: This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy. FDA is not aware of scientific evidence to support homeopathy as effective.Label: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos. Drug Label Info. Safety ...Label: BRILLIA ADULT- lapine s-100 immune globulin 12 hpc, 30 hpc, 200 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos. Drug Label Info. Safety ...LAPINE S-100 IMMUNE GLOBULIN: Common Name : ... HUMAN S-100 IMMUNE GLOBULIN RABBIT: Common Name : English : View: View: Items per page: 10. 1 – 2 of 2 . Codes ... Bookmark & Share ... < previous | pageBrillia uses the combined sciences of homeopathy and antibodies, which is a new way of treatment. The active ingredient of Brillia, Lapine S-100 immune globulin, is produced using antibodies to the brain-specific S-100 protein (S-100B), which acts as an essential regulator for many different intracellular and extracellular brain processes. LAPINE S-100 IMMUNE GLOBULIN A4FH976KAQ Other Approval Year Unknown. 134361. Substance Class: Structurally Diverse Created. by admin. on Thu Jul 06 19:37: ... Label: BRILLIA HEALTH COUGH CONTROL (lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin- 12c, 30c, 50c tabletLabel: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos. Drug Label Info. Safety ...nausea, vomiting, diarrhea, bloating, stomach pain; itching, rash, or other skin problems; cold or flu symptoms such as stuffy nose, sneezing, sore throat, cough; headache, migraine; or. pain anywhere in your body. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.Label: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos. Drug Label Info. Safety ...BRILLIA HEALTH COUGH CONTROL (lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin- 12c, 30c, 50c tablet If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be specified as such. Generic name: immune globulin intravenous. 7.0. 2 reviews. Asceniv ( Pro) Generic name: immune globulin intravenous. 10. 2 reviews. Rhophylac ( Pro) Generic name: rho (d) immune globulin.Jul 2, 2014 · Circulating S100B is taken up by peripheral immune cells. AlexaFlour 488-tagged S100B protein accumulated in Langerhans cells of the skin (A1, 2), thymic dendritic cells (B1, 2), and in dendritic cells in lymph nodes (a para-aortic lymph node is shown in C1, 2). Note the lack of uptake by non-immune surrounding tissue. Label: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos. Drug Label Info. Safety ...ACTIVE INGREDIENT. Active ingredients. Lapine S-100 immune globulin 12C, 30C, and 50C. INACTIVE INGREDIENT. Inactive Ingredients. Lactose monohydrate, Magnesium stearate, Microcrystaline cellulose. KEEP OUT OF REACH OF CHILDREN. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.Feb 16, 2023 · nausea, vomiting, diarrhea, bloating, stomach pain; itching, rash, or other skin problems; cold or flu symptoms such as stuffy nose, sneezing, sore throat, cough; headache, migraine; or. pain anywhere in your body. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Active ingredients - Lapine S-100 immune globulin 12C, 30C, and 50C. Inactive Ingredients - Lactose monohydrate, Magnesium stearate, Microcrystaline cellulose. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Keep out of reach of children. Label: BRILLIA ADULT- lapine s-100 immune globulin 12 hpc, 30 hpc, 200 hpc pill. DISCLAIMER: This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy. FDA is not aware of scientific evidence to support homeopathy as effective.BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill Hadaf LLC Disclaimer: This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy. FDA is not aware of scientific evidence to support homeopathy as effective. a new way to combine homeopathy and antibody science. The active ingredient of Brillia, Lapine S-100 immune globulin, is produced using antibodies to the brain-specific S-100 protein (S-100B). This protein is an essential regulator of many different intracellular and extracellular brain processes, e.g., various enzyme activities, BRILLIA HEALTH COUGH CONTROL (lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin- 12c, 30c, 50c tablet If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be specified as such. you have had an allergic reaction to an immune globulin or blood product; or. you have immune globulin A (IgA) deficiency with antibody to IgA. You may not be able to use Hizentra if you have ever had an allergic reaction to polysorbate 80, or if you have a condition called hyperprolinemia (high level of a certain amino acid in the blood).Active ingredients - Lapine S-100 immune globulin 12C, 30C, and 50C. Inactive Ingredients - Lactose monohydrate, Magnesium stearate, Microcrystaline cellulose. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Keep out of reach of children. FIGURE 1. Figure 1. Involvement of S100 proteins in stress and inflammation-mediated responses. Cell stress or inflammation induce the release of S100 proteins to acellular compartment where they bind cell surface receptors such as RAGE, TLR4, CD147, and GPCR. The interactions between S100 proteins and their receptors activate intracellular ...Active ingredients - Lapine S-100 immune globulin 12C, 30C, and 50C. Inactive Ingredients - Lactose monohydrate, Magnesium stearate, Microcrystaline cellulose. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Keep out of reach of children.Generic name: immune globulin intravenous. 7.0. 2 reviews. Asceniv ( Pro) Generic name: immune globulin intravenous. 10. 2 reviews. Rhophylac ( Pro) Generic name: rho (d) immune globulin. Label: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos ... Brillia’s active ingredient is Lapine S-100B immune globulin, which is produced using antibodies. S-100B is a protein in the brain that is essential for regulating many processes,...HUMAN S-100 IMMUNE GLOBULIN. Record Version. 5. Tags. Show Definitional References. ... LAPINE S-100 IMMUNE GLOBULIN . ACTIVE MOIETY : View: View 1 references: Items ...The active ingredient of Brillia, Lapine S-100 immune globulin, is produced using antibodies to the brain-specific S-100 protein (S-100B). This protein is an essential regulator of many different intracellular and extracellular brain processes, e.g., various enzyme activities, calcium homeostasis, communication between neurons, etc. Label: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos. Drug Label Info. Safety ...Circulating S100B is taken up by peripheral immune cells. AlexaFlour 488-tagged S100B protein accumulated in Langerhans cells of the skin (A1, 2), thymic dendritic cells (B1, 2), and in dendritic cells in lymph nodes (a para-aortic lymph node is shown in C1, 2). Note the lack of uptake by non-immune surrounding tissue.Label: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos ...Label: BRILLIA ADULT- lapine s-100 immune globulin 12 hpc, 30 hpc, 200 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos ... lapine cd4 immune globulin. part/fraction -> parent organism 167up2f40i. oryctolagus cuniculus hip joint. part/fraction -> parent organism wsn577vl7h.The source material of Immune Globulin (Human) shall be plasma recovered from Whole Blood prepared as prescribed in §§ 640.1 through 640.5, or Source Plasma prepared as prescribed in §§ 640.60 through 640.76. (c) Additives in source material.The tablet comprises a Lapine S-100 immune globulin mixture of homeopathic dilutions 12C, 30C, and 50C. How Does Brillia Work? Brillia is a cumulative three-months-on, one-month-off program — it doesn’t have to be taken every month since the effects are cumulative.Label: BRILLIA ADULT- lapine s-100 immune globulin 12 hpc, 30 hpc, 200 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos ...Label: BRILLIA ADULT- lapine s-100 immune globulin 12 hpc, 30 hpc, 200 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos. Drug Label Info. Safety ...Nov 20, 2022 · Label: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos. Drug Label Info. Safety ... increased sensitivity of the eyes to sunlight. increased sweating. increased thirst. irritability. joint or muscle pain. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals. loss of appetite loss of consciousness. lower back or side pain. mood or mental changes.Flu-like symptoms are the most frequent adverse effects. These include flushing, nausea, fatigue, fever, chills, malaise, and lethargy. One retrospective study showed that 14 of 16 (87.5%) patients developed flu-like symptoms during immunoglobulin administration ( 16 ).National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966Label: BRILLIA ADULT- lapine s-100 immune globulin 12 hpc, 30 hpc, 200 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos ... Tell your health care professional right away if you experience any side effects such as flushing, chills, muscle cramps, back/ joint pain, fever, nausea, vomiting, or shortness of breath. The...Difficulty having a bowel movement (stool) headache. increased urination. nausea. stomach cramps. ACTIVE INGREDIENT. Active ingredients. Lapine S-100 immune globulin 12C, 30C, and 50C. INACTIVE INGREDIENT. Inactive Ingredients. Lactose monohydrate, Magnesium stearate, Microcrystaline cellulose. KEEP OUT OF REACH OF CHILDREN. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Tell your health care professional right away if you experience any side effects such as flushing, chills, muscle cramps, back/ joint pain, fever, nausea, vomiting, or shortness of breath. The...BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill Out of scope - Out of scope for RxNorm and will not receive RxNorm normal forms. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. Active Ingredient: Lapine S-100 immune globulin mixture of homeopathic dilutions 12C, 30C and 50C. Brillia is a unique combination of antibody science and homeopathic formulation. The active ingredient of Brillia is antibodies to the brain-specific S100 protein (S100B).SEARCH RESULTS for: IMMUNE GLOBULIN (63 results) ShareDec 24, 2022 · Artificially-acquired passive immunity is an immediate, but short-term immunization provided by the injection of antibodies, such as gamma globulin, that are not produced by the recipient’s cells. These antibodies are developed in another individual or animal and then injected into another individual. Label: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos ...ACTIVE INGREDIENT. Active ingredients. Lapine S-100 immune globulin 12C, 30C, and 50C. INACTIVE INGREDIENT. Inactive Ingredients. Lactose monohydrate, Magnesium stearate, Microcrystaline cellulose. KEEP OUT OF REACH OF CHILDREN. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.you have had an allergic reaction to an immune globulin or blood product; or. you have immune globulin A (IgA) deficiency with antibody to IgA. You may not be able to use Hizentra if you have ever had an allergic reaction to polysorbate 80, or if you have a condition called hyperprolinemia (high level of a certain amino acid in the blood).Lapine HYPERLINK S-100B Immune Globulin. This consists of antibodies that target the S100B protein to reduce anxiety. They are related to a protein that can be found in the brain known as S100B. The protein regulates various processes in the brain, such as enzyme activities and calcium homeostasis.BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill Out of scope - Out of scope for RxNorm and will not receive RxNorm normal forms. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food.Brillia (Children's) Active ingredients Lapine S-100 immune globulin 12C, 30C, and 50C Inactive Ingredients Lactose monohydrate, Magnesium stearate, Microcrystaline cellulose Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Uses reduce feelings of anxiety, excitability, and stressActive ingredients - Lapine S-100 immune globulin 12C, 30C, and 50C. Inactive Ingredients - Lactose monohydrate, Magnesium stearate, Microcrystaline cellulose. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Keep out of reach of children.
Artificially-acquired passive immunity is an immediate, but short-term immunization provided by the injection of antibodies, such as gamma globulin, that are not produced by the recipient’s cells. These antibodies are developed in another individual or animal and then injected into another individual.. Maryland lottery 3 and 4
Label: BRILLIA HEALTH COUGH CONTROL (lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin- 12c, 30c, 50c tablet Immune globulin injection is used to prevent infections or make the infection less severe (eg, hepatitis A with not more than 2 weeks of exposure, chickenpox, measles with not more than 6 days of exposure, has not been vaccinated, and has not had measles previously, or rubella) when your body has a weak immune system. Immune globulin contains ...Mechanisms of action of immune globulin. Immunoglobulins are antibodies synthesized by B lymphocytes – plasma cells that can recognize a broad spectrum of specific antigenic determinants, constituting the basis of the humoral immune response. The unique structure of the immunoglobulin molecule ensures the large repertoire of specificities of ...Label: BRILLIA HEALTH COUGH CONTROL (lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin- 12c, 30c, 50c tablet you have had an allergic reaction to an immune globulin or blood product; or. you have immune globulin A (IgA) deficiency with antibody to IgA. You may not be able to use Hizentra if you have ever had an allergic reaction to polysorbate 80, or if you have a condition called hyperprolinemia (high level of a certain amino acid in the blood).Jan 1, 2023 · Lapine HYPERLINK S-100B Immune Globulin. This consists of antibodies that target the S100B protein to reduce anxiety. They are related to a protein that can be found in the brain known as S100B. The protein regulates various processes in the brain, such as enzyme activities and calcium homeostasis. Tell your health care professional right away if you experience any side effects such as flushing, chills, muscle cramps, back/ joint pain, fever, nausea, vomiting, or shortness of breath. The...BRILLIA HEALTH COUGH CONTROL- lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin (12c, 30c, 50c) tablet Hadaf LLC. Disclaimer: This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy.BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill Out of scope - Out of scope for RxNorm and will not receive RxNorm normal forms. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. Find patient medical information for immune globulin (human) (IgG) intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. ACTIVE INGREDIENT. Active ingredients. Lapine S-100 immune globulin 12C, 30C, and 50C. INACTIVE INGREDIENT. Inactive Ingredients. Lactose monohydrate, Magnesium stearate, Microcrystaline cellulose. KEEP OUT OF REACH OF CHILDREN. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. LAPINE S-100 IMMUNE GLOBULIN: Common Name : ... HUMAN S-100 IMMUNE GLOBULIN RABBIT: Common Name : English : View: View: Items per page: 10. 1 – 2 of 2 . Codes ...Label: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos. Drug Label Info. Safety ...Feb 26, 2021 · increased blood pressure, fast heartbeats; dizziness, tiredness, lack of energy; stuffy nose, sinus pain; or. pain, swelling, burning, or irritation around the IV needle. This is not a complete ... Mechanisms of action of immune globulin. Immunoglobulins are antibodies synthesized by B lymphocytes – plasma cells that can recognize a broad spectrum of specific antigenic determinants, constituting the basis of the humoral immune response. The unique structure of the immunoglobulin molecule ensures the large repertoire of specificities of ... .
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